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Pharmaceutical centrifuge has the characteristics of good adaptability, high degree of automation, stable operation, strong technology, good corrosion resistance, good operating environment, complete and reliable safety protection devices, beautiful appearance and so on. The centrifuges used in the refining process such as drug purification are generally low-speed centrifuges, and the rotating speed is less than 4000 rpm, and the processing capacity is large. In order to meet the GMP specifications and requirements in drug production, the centrifuge is generally made of flat stainless steel.
There are many kinds of medical centrifuges.
According to the separation purpose, it can be divided into laboratory medicine centrifuge and industrial medicine centrifuge.
According to the structure, it can be divided into table type and floor type.
According to the temperature control, it can be divided into frozen medical centrifuge and normal temperature medical centrifuge.
According to the separation components, it can be divided into: Medical solid-liquid separation centrifuge and medical liquid-liquid separation centrifuge.
According to the capacity, it can be divided into micro medical centrifuge, small capacity medical centrifuge and large capacity pharmaceutical centrifuge.
In terms of function, pharmaceutical centrifuge has the following advantages:
1. The material has strong adaptability. By selecting appropriate filter media, it can separate millimeter sized fine particles, and can also be used for dehydration of finished articles. The articles can be cleaned through water washing pipes.
2. The manual upper unloading type has the advantages of simple structure, convenient installation, low cost, easy operation, and can keep the grain shape of the product.
3. The machine adopts advanced elastic support structure, which can reduce the vibration caused by uneven load, and the machine runs smoothly.
4. The whole high-speed running structure is concentrated in a closed shell, which can realize sealing and avoid material pollution.
For low-speed centrifuges, due to the strict specifications of pharmaceutical industry, it is basically flat closed type. In order to reduce possible pollution or damage or improve hygiene, stainless steel materials are used in the parts contacting with materials or the whole centrifuge is made of stainless steel materials. The whole machine has no sanitary dead angle, so it is clean and easy to use. This type of centrifuge has been widely used in the whole pharmaceutical industry, plus 3 Small centrifuges of about 1000 rpm constitute the whole system of low-speed industrial centrifuges, and also infiltrate other industries related to biomedicine. This kind of centrifuge must comply with the national GMP standards before it can be used.
The high-speed centrifuge uses DC brushless motor, maintenance free; microcomputer control, can pre select speed, time, centrifugal force, LCD display, easy to operate; 10 kinds of lifting speed for selection, can start and stop quickly; stainless steel container room, electronic door lock, early warning alarm function, a variety of protection, safe and reliable.
The technology of this kind of centrifuge is relatively simple. Generally, zone centrifuges are often used. Zone centrifuges separate and collect cells, viruses and DNA molecules according to the density and gradient of sample solution. The adding and unloading methods are continuous. Besides being widely used in production process, they are also widely used in laboratory equipment.
In the pharmaceutical industry, due to the more stringent requirements on production quality and production safety, there are also very high requirements for the main process equipment of raw material drug production process in the field of drug production such as centrifuge. In addition to maintaining its own separation characteristics, centrifuges also need to meet the requirements of relevant specifications and standards in the field of medicine. It is necessary to consider the material, structure, material input and output mode, safety, labor intensity, control, cleaning or disinfection and sterilization from the perspective of meeting the requirements of pharmaceutical production process.
There are cleaning and sterilization requirements for the change of batch and variety in the production of pharmaceutical centrifuge, so as to prevent all kinds of pollution sources and avoid being polluted again. It is necessary to work hard on automatic program control, man-machine isolation operation, easy cleaning, sterilizable structure, on-line analysis and research and improvement of separation methods of materials with different properties to enhance the level of function, control and aseptic operation.
Because the centrifuge in medical field needs to be removed from medicine, the surface of centrifuge equipment must be smooth, flat and free of dead angle. Therefore, it is necessary to ensure that the sharp corner, corner and weld of centrifuge are ground into smooth transition fillet in the manufacturing process. Due to the need for contact with drugs, centrifuges need to be corrosion-resistant and not chemically change or adsorb drugs with drugs.
With the development of centrifuges, centrifuge related technologies have been improved. However, the pharmaceutical machinery industry can not be satisfied with the status quo and must continue to develop. With the support of national policies, centrifuge enterprises should make continuous efforts to promote the wider application of centrifuges in the pharmaceutical industry.